منابع مشابه
Novel functional small RNAs are selectively loaded onto mammalian Ago1
Argonaute (Ago) proteins function in RNA silencing as components of the RNA-induced silencing complex (RISC). In lower organisms, the small interfering RNA and miRNA pathways diverge due in part to sorting mechanisms that direct distinct small RNA (sRNA) duplexes onto specific Ago-RISCs. However, such sorting mechanisms appear to be lost in mammals. miRNAs appear not to distinguish among Ago1-4...
متن کاملSmall but sturdy: small RNAs in cellular memory and epigenetics.
Cells in multicellular organisms have distinct identities characterized by their profiles of expressed genes. Cell identities can be stable over a long time and through multiple cellular divisions but are also responsive to extracellular signals. Since the DNA sequence is identical in all cells, a "cellular memory" of expression profiles is achieved by what are defined as epigenetic mechanisms....
متن کاملAbdominal incision closure: small but important bites.
www.thelancet.com Published online July 16, 2015 http://dx.doi.org/10.1016/S0140-6736(15)60687-0 1 In The Lancet, Eva Deerenberg and colleagues’ prospective, multicentre, double-blind, randomised controlled STITCH trial shows that the rate of incisional hernia is lower with small tissue bites than with large bites. This fi nding contradicts what surgeons have thought and been taught for many de...
متن کاملβ-Cell MicroRNAs: Small but Powerful
Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of key processes in cell biology, including development, differentiation, and survival. Currently, over 2,500 mature miRs have been reported in humans, and considering that each miR has multiple targets, the number of genes and pathways potentially affected is huge. Not surprisingly, many miRs have also been impl...
متن کاملA small but nonzero cosmological constant
Recent astrophysical observations seem to indicate that the cosmological constant is small but nonzero and positive. The old cosmological constant problem asks why it is so small; we must now ask, in addition, why it is nonzero (and is in the range found by recent observations), and why it is positive. In this essay, we try to kill these three metaphorical birds with one stone. That stone is th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2014
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3782